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Category:
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7TM Receptors Opioid ReceptorsKappa ReceptorsAgonists
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Cat.No.
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Product Name
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1419 |
Naloxone benzoylhydrazone
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| Alternative name(s): |
NalBzoH |
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Price and Availability
Click here for full price details of
Naloxone benzoylhydrazone
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Chemical Name:
[(5a)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan
-6-ylidene] benzoic acid hydrazide |
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Biological Activity:
Mixed
opioid receptor agonist/antagonist. Acts as an agonist at κ3 and an antagonist at μ, δ and κ1 opioid receptors (pA2
values are 8.8, 7.8 and 7.8 respectively). Also acts as an antagonist at
central and peripheral ORL1 receptors.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Gistrak et al (1989) Pharmacological
actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone.
J.Pharmacol.Exp.Ther. 251 469. Berzetei-Gurske et al
(1995) The in vitro pharmacological characterization of naloxone
benzoylhydrazone. Eur.J.Pharmacol. 277 257. Chiou et al
(2001) Differential antagonism by naloxone benzoylhydrazone of the activation
of inward rectifying K+ channels by nociceptin and a μ-opioid in rat periaqueductal grey
slices. Naunyn-Schmied.Arch.Pharmacol. 363 583.
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Keywords: Naloxone Benzoylhydrazone, Opioid Receptors, K3 Agonist. Antagonist At M, D, K1 & ORL1, NalBzoH, Tocris Bioscience
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