Chemical Name:N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-
naphthalenecarboxamide
Biological Activity:
Highly potent, competitive, preferential dopamine D3
receptor antagonist. Ki values are 0.52, 5, and 269 nM for human
cloned D3, D2 and D4 receptors respectively.
Centrally active upon systemic administration.
Sautel et al (1995) Nafadotride, a potent preferential dopamine D3
receptor antagonist, activates locomotion in rodents. J.Pharmacol.Exp.Ther. 275
1239. Audinotet al (1998) A comparative in vitro and in
vivo pharmacological characterization of the novel dopamine D3
receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194.
J.Pharmacol.Exp.Ther. 287 187. Richtandet al
(2000) The dopamine D3 receptor antagonist nafadotride inhibits
development of locomotor sensitization to amphetamine. Brain Res. 867
239.
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