NU 1025 | Polymerases | Potent PARP Inhibitor | NU1025

Category:

Cat.No.	Product Name
1401	NU 1025

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NU 1025

Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolinone

Biological Activity:

Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K_i and IC₅₀ values are 48 and 400 nM respectively.

Technical Data:

M.Wt:	176.17
Formula:	C₉H₈N₂O₂
Storage:	Store at RT
Solubility:	Soluble to 100 mM in 1eq. NaOH and to 100 mM in 1eq. HCl
Purity:	>99%
CAS No:	[90417-38-2]

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Certificate of Analysis / MSDS:

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References:

Griffin et al (1998) Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J.Med.Chem. 41 5247. Bowman et al (1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br.J.Cancer. 78 1269. Delaney et al (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin.Cancer.Res. 6 2860.

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Keywords: NU 1025, Polymerases, Potent PARP Inhibitor, NU1025, Tocris Bioscience

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