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Category:
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Enzymes PhosphatasesCdc25
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Cat.No.
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Product Name
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1867 |
NSC 663284
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Price and Availability
Click here for full price details of
NSC 663284
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Chemical Name:
6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolin
edione |
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Biological Activity:
Potent, selective inhibitor of Cdc25 dual
specificity phosphatases (Ki values are 29, 95 and 89 nM for human
Cdc25A, Cdc25B2 and Cdc25C respectively); > 20- and > 450-fold
selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1
and G2/M phase and blocks cdk2 and cdk1 activation. Blocks
proliferation of a range of human tumour cell lines (IC50 = 0.2-35 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Lazo et al (2001)
Discovery and biological evaluation of a new family of potent inhibitors of the
dual specificity protein phosphatase Cdc25. J.Med.Chem. 44 4042. Pu
et al (2002) Dual G1 and G2 phase inhibition by a
novel, selective Cdc25 inhibitor
7-chloro-6-(2-morpholin-4-ylethylamino)-quinoline-5,8-dione. J.Biol.Chem. 277
46877. Brisson et al (2005) Redox regulation of cdc25B by
cell-active Quinolinediones. Mol.Pharmacol. 68 1810.
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Keywords: NSC 663284, Phosphatases, Potent, Selective Cdc25 Phosphatase Inhibitor, NSC663284, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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