NNC 26-9100 | Peptides (Hypothalamic / Pituitary Hormones) | Selective Sst4 Agonist | NNC26-9100

Category:

Peptides (Hypothalamic/Pituitary Hormones)

Cat.No.	Product Name
2440	NNC 26-9100

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NNC 26-9100

Chemical Name: 1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)ami no]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea

Biological Activity:

Somatostatin sst₄ receptor agonist that displays > 100-fold selectivity over sst₂ receptors (K_i values are 6 and 621 nM for sst₄ and sst₂ receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC₅₀ = 26 nM).

Technical Data:

M.Wt:	556.35
Formula:	_{C22H25N6Cl2SBr}
Storage:	Store at +4°C
Solubility:	Soluble to 50 mM in DMSO and to 50 mM in Ethanol
Purity:	>99%
CAS No:	[199522-35-5]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Liu et al (1998) Nonpeptide somatostatin agonists with sst₄ selectivity: synthesis and structure-activity relationships of thioureas. J.Med.Chem. 41 4693. Liu et al (1999) 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. Curr.Pharm.Des. 5 255.

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Keywords: NNC 26-9100, Peptides (Hypothalamic / Pituitary Hormones), Selective Sst4 Agonist, NNC26-9100, Tocris Bioscience

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