|
Category:
|
Transporters Neurotransmitter TransportersGABA Transporters
|
|
Cat.No.
|
Product Name
|
|
2747 |
NNC 05-2090 hydrochloride
|
|
|
|
Price and Availability
Click here for full price details of
NNC 05-2090
|
|
Chemical Name:
1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-pi
peridinol hydrochloride |
|
|
Biological Activity:
GABA uptake inhibitor that displays moderate
selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15,
19 and 41 μM
for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits
sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays
affinity at α1-
and D2-receptors (IC50 values are 266 and 1632 nM
respectively).
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Thomsen et al
(1997) 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a
novel subtype selective inhibitor of the mouse type II GABA-transporter.
Br.J.Pharmacol. 120 983. Dalby et al (1997)
Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC
05-2090, not acting preferentially on GAT-1. Epilepsy Res. 28 51.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: NNC 05-2090, Neurotransmitter Transporters, GABA Uptake Inhibitor; Moderately BGT-1 Selective, NNC05-2090, Tocris Bioscience
|
|
|
