Chemical Name:N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy
)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pe
ntamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester
b-alanine hydrochloride
Biological Activity:
Water-soluble analogue of forskolin (Cat. No.
1099) that is a potent activator of adenylyl cyclase; shows some selectivity
for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC50
= 32.6 nM) and is an orally active potent positive chronotrope and hypotensive
agent in vivo.
Hosonoet al (1992)
Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel
water-soluble forskolin derivative. J.Cardiovasc.Pharmacol. 19
625. Satakeet al (1998) Relaxant effects of NKH477, a new
water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: the
role of Ca2+-activated K+ channels. Br.J.Pharmacol. 123
753. Toyaet al (1998) Forskolin derivatives with increased
selectivity for cardiac adenylyl cyclase. J.Mol.Cell.Cardiol. 30
97.
