L-NIO Dihydrochloride | Synthases / Synthetases | Potent ENOS Inhibitor | LNIO Dihydrochloride

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Cat.No.	Product Name
0546	L-NIO dihydrochloride

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L-NIO dihydrochloride

Chemical Name: N5-(1-Iminoethyl)-L-ornithine dihydrochloride

Biological Activity:

Potent inhibitor of endothelial NO synthase (IC₅₀ = 500 nM). Also inhibits iNOS and nNOS. Active in vivo.

Technical Data:

M.Wt:	261.15
Formula:	C₇H₁₅N₃O₂.2HCl
Storage:	Desiccate at -20°C
Solubility:	Soluble to 100 mM in Water
CAS No:	[36889-13-1]

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References:

Rees et al (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 101 746. Mulligan et al (1992) Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 107 1159. Moncada et al (1997) XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 49 137.

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Keywords: L-NIO Dihydrochloride, Synthases / Synthetases, Potent ENOS Inhibitor, LNIO Dihydrochloride, Tocris Bioscience

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