Chemical Name:1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuran
uronamide
Biological Activity:
Potent adenosine receptor agonist (Ki
values are 14, 20 and 6.2 nM for human A1, A2A and A3
receptors respectively; EC50 = 2.4 μM
for human A2B). Inhibits platelet aggregation and is centrally
active in vivo.
Cusack
and Hourani (1981)
5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet
aggregation. Br.J.Pharmacol. 72 443. Klotz (2000)
Adenosine receptors and their ligands. Naunyn-Schmied.Arch.Pharmacol. 362
382. Knappet al (2001) Adenosine agonists CGS21680 and NECA
inhibit the initiation of cocaine self-administration. Pharmacol.Biochem.Behav.
68 797.
“Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..”
