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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA / Kainate SelectivearrowAntagonists
Cat.No. Product Name
0373

NBQX  

Price and Availability

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NBQX

Other Information:

Sold with the permission of Novo Nordisk A/S
Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline -7-sulfonamide

Biological Activity:

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.

Technical Data:

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M.Wt: 336.28
Formula: C12H8N4O6S
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO
Purity: >98%
CAS No: [118876-58-7]

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    References:

    Gill et al (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580 35. Zeman and Lodge (1992) Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 106 367. Sheardown et al (1993) The pharmacology of AMPA receptors and their antagonists. Stroke 24 Suppl I 146. Namba et al (1994) Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638 36.

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    Keywords: NBQX, Ligand-gated Ion Channels, Potent AMPA / Kainate Antagonist, More Selective Than CNQX (Cat. No. 0190), Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    The Ins & outs of Glutamate Transporter Pharmacology
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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