NBMPR | Neurotransmitter Transporters | Equilibrative Nucleoside Transporter 1 (ENT1) Inhibitor

Category:

Cat.No.	Product Name
2924	NBMPR

Price and Availability

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NBMPR

Chemical Name: 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine

Biological Activity:

Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K_i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Technical Data:

M.Wt:	419.41
Formula:	C₁₇H₁₇N₅O₆S
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in DMSO
Purity:	>99%
CAS No:	[38048-32-7]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Ward et al (2000) Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J.Biol.Chem. 275 8375. Tsujie et al (2007) Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 27 2241. Lin and Buolamwini (2007) Synthesis and flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906.

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Keywords: NBMPR, Neurotransmitter Transporters, Equilibrative Nucleoside Transporter 1 (ENT1) Inhibitor, Tocris Bioscience

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Nucleotide & Nucleoside Receptors
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