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Category:
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Cellular Processes and Components Cytoskeleton and Motor ProteinsActin
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Cat.No.
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Product Name
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2067 |
187-1, N-WASP inhibitor
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Price and Availability
Click here for full price details of
187-1, N-WASP inhibitor
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Biological Activity:
Inhibits
neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilising the
autoinhibited state of the protein. Blocks phosphatidylinositol
4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~
2 μM) but does not directly inhibit
actin polymerisation.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Peterson et al (2001) A chemical
inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.
Proc.Natl.Acad.Sci.USA 98 10624. Suetsugu et al
(2001) Identification of another actin-related (Arp) 2/3 complex binding site
in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin
polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP.
J.Biol.Chem. 276 33175. Prehoda and Lim (2002) How
signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2.
Curr.Opin.Cell Biol. 14 149.
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Keywords: 187-1, N-WASP Inhibitor, Cytoskeleton & Motor Proteins, Inhibits Actin Assembly, 1871, N-WASP Inhibitor, Tocris Bioscience
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