Monastrol | Cytoskeleton & Motor Proteins | Selective Inhibitor Of Mitotic Kinesin Eg5

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Cat.No.	Product Name
1305	Monastrol

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Monastrol

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Sold with the permission of Harvard University

Chemical Name: 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thiox o-5-pyrimidinecarboxylic acid, ethyl ester

Biological Activity:

Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC₅₀ = 14 μM).

Technical Data:

M.Wt:	292.35
Formula:	C₁₄H₁₆N₂O₃S
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Ethanol
Purity:	>98%
CAS No:	254753-54-3

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References:

Mayeret al (1999) Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286 971. Kapoor et al (2000) Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J.Cell Biol. 150 975.

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Keywords: Monastrol, Cytoskeleton & Motor Proteins, Selective Inhibitor Of Mitotic Kinesin Eg5, Tocris Bioscience

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