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Category:
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7TM Receptors Adrenergic ReceptorsAdrenergic-Related Compounds
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Cat.No.
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Product Name
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1811 |
Modafinil
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| Alternative name(s): |
CRL 40476 |
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Price and Availability
Click here for full price details of
Modafinil
Other Information:
DEA controlled substance.
Please consult your local
office for further information
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Chemical Name:
2-[(Diphenylmethyl)sulfinyl]acetamide |
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Biological Activity:
Psychostimulant that displays neuroprotective
and antiParkinsonian activity in a primate model of Parkinson's disease.
Promotes vigilence and wakefulness without the central and peripheral side
effects associated with conventional dopaminergic psychostimulants. Mechanism
of action is not fully understood, possibly via modulation of
catecholamine/GABAergic neurotransmission.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ferraro et al
(1997) Modafinil: an antinarcoleptic drug with a different neurochemical
profile to d-amphetamine and dopamine uptake blockers. Biol.Psychiatry 42
1181. Jenner et al (2000) AntiParkinsonian and neuroprotective
effects of modafinil in the mtpt-treated common marmoset. Exp.Brain Res. 133
178. Madras et al (2006) Modafinil occupies dopamine and
norepinephrine transporters in vivo and modulates the transporters and trace amine
activity in vitro. J.Pharmacol.Exp.Ther. 319 561.
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or by Research Area
Keywords: Modafinil, Adrenergic Receptors, Psychostimulant, CRL 40476, Tocris Bioscience
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