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Category:
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Enzymes PolymerasesRNA/DNA Polymerase
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Cat.No.
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Product Name
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1489 |
Mithramycin A
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Price and Availability
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Mithramycin A
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Chemical Name:
(1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dide
oxy-b-D-arabino-hexopyranosyl)-b-D-arabino-hexopyranosy
l]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-b-D-ribo-hexopyrano
syl-(1.fwdarw.3)-O-2,6-dideoxy-b-D-lyxo-hexopyranosyl-(
1.fwdarw.3)-2,6-dideoxy-b-D-arabino |
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Biological Activity:
Anticancer antibiotic that selectively binds to
G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting
RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid
differentiation of HL-60 promyelocytic leukemia cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Miller et al
(1987) Mithramycin selectively inhibits transcription of G-C containing DNA.
Am.J.Med.Sci. 294 388. Ray et al (1990) Mithramycin
selectively inhibits the transcriptional activity of a transfected human c-myc
gene. Am.J.Med.Sci. 300 203. Demicheli and Garnier-Suillerot
(1991) Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of
Mg2+ ion. Biochem.Biophys.Res.Commun. 177 511.
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or by Research Area
Keywords: Mithramycin A, Polymerases, Inhibitor Of DNA & RNA Polymerase, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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