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Category:
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Nuclear Receptors Progesterone Receptor
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Cat.No.
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Product Name
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1479 |
Mifepristone
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| Alternative name(s): |
RU 486 |
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RU 38486 |
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Price and Availability
Click here for full price details of
Mifepristone
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Chemical Name:
(11b,17
b)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propyn
yl)-estra-4,9-dien-3-one |
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Biological Activity:
Selective
antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and
in vivo. Is a silent antagonist at PR and has a higher affinity than
progesterone. Has higher affinity for GR than dexamethasone.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Schrieber et al (1983) Binding of the
anti-progestin RU 486 to rat ovary steroid receptors. Contraception 28
77. Gagne et al (1985) RU 38486: a potent antiglucocorticoid in
vitro and in vivo. J.Steroid Biochem. 23 247. Mao et al (1992) Molecular mechanism
of RU 486 action: a review. Mol.Cell.Biochem. 109 1.
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View related products by Pharmacological Action
or by Research Area
Keywords: Mifepristone, Progesterone Receptor, Progesterone & Glucocorticoid Antagonist, RU 486, RU 38486, Tocris Bioscience
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