Methylthio-ADP, 2- | P2Y Receptors | Potent Agonist For P2Y1, P2Y12 & P2Y13 | 2-(Methylthio)adenosine 5-diphosphate

Category:

7TM Receptors

P2Y Receptors

Agonists

Cat.No.

Product Name

1624

2-Methylthio-ADP trisodium salt

Alternative name(s):

2-(Methylthio)adenosine 5'-diphosphate

Methylthio-ADP, 2- C11H14N5Na3O10P2S 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt

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Methylthio-ADP, 2-

Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt

Biological Activity:

Potent purinergic agonist displaying selectivity for P2Y₁, P2Y₁₂ and P2Y₁₃ receptors (pEC₅₀ = 8.29 and 9.05 for P2Y₁and P2Y₁₂, EC₅₀ = 19 nM for P2Y₁₃). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data:

M.Wt:	539.24
Formula:	C₁₁H₁₄N₅Na₃O₁₀P₂S
Storage:	Store at -20°C
Solubility:	Soluble to 10 mM in Water (supplied predissolved at a concentration of 10mM)
Purity:	>98%
CAS No:	[34983-48-7]

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References:

Macfarlane et al (1983) 2-Methylthioadenosine[β-³²P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420. Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131. Zhang et al (2002) P2Y₁₃: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705.

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Keywords: Methylthio-ADP, 2-, P2Y Receptors, Potent Agonist For P2Y1, P2Y12 & P2Y13, 2-(Methylthio)adenosine 5-diphosphate, Tocris Bioscience

Literature in this Area

Scientific Reviews

Nucleotide & Nucleoside Receptors
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“Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..”

Researcher, University of Aberdeen, UK

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