Click here for full price details of Methyllycaconitine citrate
Chemical Name:[1a,4(S),6b,14a,16b]-20-Ethyl-1,6,14,16-tetramethoxy-4-
[[[2-(3-methyl-2,5-
dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-d
iol citrate
Biological Activity:
Potent antagonist for α7-containing
neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2
and α6β2 receptors at
concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse
striatum in vivo.
Wardet
al (1990) Methyllycaconitine: a selective probe for neuronal α-bungarotoxin
binding sites. FEBS Lett. 270 45. Dobeliset al
(1999) Effects of delphinium alkaloids on neuromuscular transmission.
J.Pharmacol.Exp.Ther. 291 538. Escubedoet al (2005)
Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum:
involvement of a7 nicotinic receptors. J.Pharmacol.Exp.Ther. 315
658.
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