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Category: Ion ChannelsarrowLigand-gated Ion Channelsarrow5-HT3 ReceptorsarrowAgonists
Cat.No. Product Name
0558 2-Methyl-5-hydroxytryptamine hydrochloride
Price and Availability

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2-Methyl-5-hydroxytryptamine hydrochloride

Biological Activity:

5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM).

Technical Data:

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M.Wt: 226.71
Formula: C11H14N2O.HCl
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
Purity: >98%
CAS No: [78263-90-8]

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    References:

    Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683. Ismaiel et al (1990) 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 33 755. Craig et al (1990) 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn.Schmied.Arch.Pharmacol. 342 9. Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011.

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    Keywords: 2-Methyl-5-hydroxytryptamine Hydrochloride, Ligand-gated Ion Channels, 5-HT3 Agonist / Potent 5-ht6 Ligand, 2Methyl-5-hydroxytryptamine Hydrochloride, Tocris Bioscience
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