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Category: 7TM ReceptorsarrowHistamine ReceptorsarrowH3 and H4 ReceptorsarrowAgonists
Cat.No. Product Name
0569 (R)-(-)-a-Methylhistamine dihydrobromide  
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(R)-(-)-a-Methylhistamine dihydrobromide
Chemical Name: (R)-(-)-a-Methyl-1H-imidazole-4-ethanamine dihydrobromide

Biological Activity:

Very potent, high affinity H3  agonist; displays > 200-fold selectivity over H4 receptors. Inhibits H3-mediated histamine synthesis and release in the CNS and stimulates H4-mediated eosinophil shape change (EC50 = 66 nM).

Technical Data:

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M.Wt: 287
Formula: C6H11N3.2HBr
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
CAS No: [75614-87-8]

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    References:

    Oishi et al (1989) Effects of histamine H3-agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine modulation in the mouse and rat brain. J.Neurochem. 52 1388. Hew et al (1990) Characterization of histamine-H3 receptors in guinea pig ileum with H3-selective ligands. Br.J.Pharmacol. 101 621. Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13. Buckland et al (2003) Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor. Br.J.Pharmacol. 140 1117.
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    Keywords: (R)-(-)-a-Methylhistamine Dihydrobromide, Histamine Receptors, Potent, Standard H3 Agonist, Alpha-Methylhistamine Dihydrobromide, Tocris Bioscience
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