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Category:
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Cellular Processes and Components ApoptosisApoptosis Inducer
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Cat.No.
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Product Name
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1807 |
2-Methoxyestradiol
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Price and Availability
Click here for full price details of
2-Methoxyestradiol
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Chemical Name:
(17b)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol |
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Biological Activity:
Apoptotic, antiproliferative and antiangiogenic
agent, in vitro and in vivo; acts via an estrogen receptor-independent
mechanism. Induces p53-induced apoptosis via two pathways: activation of p38
and NF-κB;
and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also
upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
D'Amato
et al (1994) 2-Methoxyestradiol, an
endogenous mammalian metabolite, inhibits tubulin polymerization by interacting
at the colchicine site. Proc.Natl.Acad.Sci.USA 91 3964. LaVallee
et al (2002) 2-Methoxyestradiol inhibits proliferation and induces
apoptosis independently of estrogen receptors alpha and beta. Cancer Res. 62
3691. LaVallee et al (2003) 2-Methoxyestradiol up-regulates death
receptor 5 and induces apoptosis through activation of the extrinsic pathway.
Cancer Res. 63 468. Shimada et al (2003) Roles of
p38 and c-jun NH2-terminal kinase-mediated pathways in
2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24
1067.
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View related products by Pharmacological Action
or by Research Area
Keywords: 2-Methoxyestradiol, Apoptosis, Apoptotic & Antiangiogenic Agent, 2Methoxyestradiol, Tocris Bioscience
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