Methiothepin Maleate | 5-HT Receptors | Has Moderate Affinity For 5-ht5 & High Affinity For 5-ht6 & 5-HT7. Also Antagonist At 5-HT1 & 5-HT2 | Metitepine

Category:

7TM Receptors

5-HT Receptors

Serotonergic-Related

Cat.No.

Product Name

0582

Methiothepin maleate

Alternative name(s):

Metitepine

Methiothepin maleate
C20H24N2S2.C4H4O4 1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine maleate

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Methiothepin maleate

Chemical Name: 1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-y l]-4-methylpiperazine maleate

Biological Activity:

Potent 5-HT₂ antagonist, also active as 5-HT₁ antagonist. Differentiates 5-HT_1D sub-types.

Technical Data:

M.Wt:	472.62
Formula:	C₂₀H₂₄N₂S₂.C₄H₄O₄
Storage:	Store at RT
Solubility:	Soluble to 5 mM in Water
CAS No:	[20229-30-5]

Resources:

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References:

Monachon et al (1972) Blockade of central 5-hydroxytryptamine receptors by methiothepin. Naunyn.Schmied.Arch.Pharmacol. 274 192. Hoyer (1989) The peripheral actions of 5-HT. Ed. Fozard. 0 72, Oxford. Wilkinson and Middlemiss (1992) Metitepine distinguishes two receptors mediating inhibition of [³H]-5-hydroxytryptamine release in guinea pig hippocampus. Naunyn.Schmied.Arch.Pharmacol. 345 696.

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Keywords: Methiothepin Maleate, 5-HT Receptors, Has Moderate Affinity For 5-ht5 & High Affinity For 5-ht6 & 5-HT7. Also Antagonist At 5-HT1 & 5-HT2, Metitepine, Tocris Bioscience

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Scientific Reviews

5-HT Receptors & their Ligands
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