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Category: EnzymesarrowKinasesarrowOther Kinases
Cat.No. Product Name
2864 Metformin hydrochloride
Price and Availability

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Metformin
Chemical Name: N,N-Dimethylimidodicarbonimidic diamide hydrochloride

Biological Activity:

Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines.

Technical Data:

 Click here for more information on batch specific data
M.Wt: 165.62
Formula: C4H11N5.HCl
Storage: Store at RT
Solubility: Soluble to 100 mM in Water and to 50 mM in DMSO
CAS No: [1115-70-4]

Resources:

    		•

    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Shaw et al (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642. Zakikhani et al (2006) Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 66 10269. Towler and Hardie (2007) AMP-activated protein kinase in metabolic control and insulin signalling. Circ.Res. 100 328.
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    Keywords: Metformin, Kinases, Activator Of LKB1 / AMPK; Antidiabetic Agent, Tocris Bioscience
    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    Product Feature
    Kinase Inhibitors
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