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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT2 ReceptorsarrowNon-selective 5-HT2
Cat.No. Product Name
0590 Metergoline  
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Metergoline phenylmethyl ester
Chemical Name: [(8ß)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester

Biological Activity:

Antagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-ht6 and high affinity for 5-HT7.

Technical Data:

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M.Wt: 403.52
Formula: C25H29N3O2
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO
CAS No: [17692-51-2]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Bagdy et al (1992) Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur.J.Pharmacol. 210 285. Miller et al (1992) Agonist activity of sumatriptan and metergoline at the human 5-HT1Db receptor in the action of sumatriptan. Eur.J.Pharmacol. 227 99. Aulakh et al (1992) Effects of various serotonin receptor subtype selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. J.Pharmacol.Exp.Ther. 263 588.
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    Keywords: Metergoline Phenylmethyl Ester, 5-HT Receptors, 5-HT2 Antagonist. Also 5-HT1 Antagonist & 5-HT1D Ligand. Has Moderate Affinity For 5-ht6 & High Affinity For 5-HT7, Tocris Bioscience
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