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Category:
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Enzymes DeacetylasesHistone Deacetylase
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Cat.No.
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Product Name
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2771 |
M 344
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Price and Availability
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M 344
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Chemical Name:
4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzam
ide |
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Biological Activity:
Histone deacetylase inhibitor (IC50
= 100 nM). Induces terminal cell differentiation and causes an increase in
hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of
human endometrial and ovarian cancer cells by inducing cell cycle arrest and
apoptosis.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Jung et
al (1999) Amide analogues of trichostatin A as inhibitors of histone
deacetylase and inducers of terminal cell differentiation. J.Med.Chem. 42
4669. Takai et al (2006) M344 is a novel synthesized histone
deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and
apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol.Oncol. 101
108. Riessland et al (2006) The benzamide M344, a novel histone
deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in
spinal muscular atrophy cells. Hum.Genet. 120 101.
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or by Research Area
Keywords: M 344, Deacetylases, Histone Deacetylase Inhibitor, M344, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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