MRS 1845 | Calcium Channels | Potent SOC Inhibitor; Blocks Capacitative Ca2+ Entry | N-Propylargylnitrendipine | MRS1845

Category:

Ion Channels

Calcium Channels

Other Calcium Channels

Cat.No.

Product Name

1866

MRS 1845

Alternative name(s):

N-Propylargylnitrendipine

MRS 1845 C21H22N2O6 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylic acid ethyl, methyl ester

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MRS 1845

Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propyny l)-3,5-pyridinedicarboxylic acid ethyl, methyl ester

Biological Activity:

Potent blocker of store-operated Ca²⁺ channels; inhibits capacitative Ca²⁺ influx in HL-60 cells (IC₅₀ = 1.7 μM).

Technical Data:

M.Wt:	398.41
Formula:	C₂₁H₂₂N₂O₆
Storage:	Store at +4°C
Solubility:	Soluble to 10 mM in Ethanol and to 10 mM in DMSO
Purity:	>98%
CAS No:	[544478-19-5]

Resources:

Certificate of Analysis / MSDS:

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References:

Harper et al (2003) Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem.Pharmacol. 65 329.

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Keywords: MRS 1845, Calcium Channels, Potent SOC Inhibitor; Blocks Capacitative Ca2+ Entry, N-Propylargylnitrendipine, MRS1845, Tocris Bioscience

Literature in this Area

Scientific Reviews

Mechanisms for Manipulating Intracellular Calcium Buffering
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