MRS 1754 | Adenosine Receptors | Selective A2B Antagonist | MRS1754

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Cat.No.	Product Name
2752	MRS 1754

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MRS 1754

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Sold with the permission of the University of Virginia Patent Foundation

Chemical Name: N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1, 3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide

Biological Activity:

Selective adenosine A_2B receptor antagonist (K_i values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA_2B, rA₁, hA₁, hA_2A, hA₃ and rA_2A receptors respectively).

Technical Data:

M.Wt:	486.52
Formula:	_C26H26N6O4
Storage:	Desiccate at RT
Solubility:	Soluble to 50 mM in DMSO
Purity:	>98%
CAS No:	[264622-58-4]

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Certificate of Analysis / MSDS:

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References:

Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A_2B adenosine receptors. J.Med.Chem. 43 1165. Ji et al (2001) [³H]MRS 1754, a selective antagonist radioligand for A_2B adenosine receptors. Biochem.Pharmacol. 61 657. Nemeth et al (2007) Adenosine receptor activation ameliorates type I diabetes. FASEB J. 21 2380.

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Keywords: MRS 1754, Adenosine Receptors, Selective A2B Antagonist, MRS1754, Tocris Bioscience

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Scientific Reviews

Nucleotide & Nucleoside Receptors
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