Sold with the permission of the NIH, US Patent
60/029,855
Chemical Name:1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyr
idinedicarboxylic acid
3-ethyl-5-[(3-nitrophenyl)methyl] ester
Biological Activity:
Potent and highly selective antagonist for the human adenosine A3
receptor. Ki values are 2.69 nM at hA3, and > 100 μM at rat A1 and rat A2A receptors.
Liet al (1998) Structure-activity relationships and
molecular modeling of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3
adenosine receptor antagonists. J.Med.Chem. 41 3186. Baraldi
and Borea (2000) New potent and selective human adenosine A3
receptor antagonists. TiPS 21 456.
“Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..”
