8-M-PDOT | Melatonin (MT) Receptors | Melatonin Agonist | 8M-PDOT

Category:

Cat.No.	Product Name
1035	8-M-PDOT

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8-M-PDOT

Chemical Name: 8-Methoxy-2-propionamidotetralin

Biological Activity:

Melatonin receptor agonist, 20-fold selective for the MT₂ (vs MT₁) subtype. At human recombinant MT₁ and MT₂ receptors, displays pK_i values of 8.23 and 8.95 respectively.

Technical Data:

M.Wt:	233.31
Formula:	C₁₄H₁₉NO₂
Storage:	Store at RT
Solubility:	Soluble to 50 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[134865-70-6]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel_1a and Mel_1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML₁ presynaptic heteroceptor. Naunyn-Schmied.Arch.Pharmacol. 355 365. Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 129 877.

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Keywords: 8-M-PDOT, Melatonin (MT) Receptors, Melatonin Agonist, 8M-PDOT, Tocris Bioscience

Literature in this Area

Scientific Reviews

Melatonin Receptors
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