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Category:
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Other Activities Miscellaneous Compounds
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Cat.No.
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Product Name
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2492 |
MNITMT
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| Alternative name(s): |
NSC 631156 |
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Price and Availability
Click here for full price details of
MNITMT
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Chemical Name:
4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H
-1,2,4-triazole |
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Biological Activity:
Novel, non-toxic immunosuppressive agent. Inhibits human mixed
lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a
98.1% reduction in antibody response following oral administration in rabbits.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Crawford et al (1996) Rational design of novel immunosuppressive
drugs: analogues of azathioprine lacking the 6-mercaptopurine substituent
retain or have enhanced immunosuppressive effects. J.Med.Chem. 39
2690. Al-Safi et al (2003) Comparison of the effects of
azathioprine and its novel non-mercaptopurine analog on antibody response in
rabbits. Pol.J.Pharmacol. 55 239.
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View related products by Pharmacological Action
or by Research Area
Keywords: MNITMT, Immunosuppressant, NSC 631156, Tocris Bioscience
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