MNI-caged-L-glutamate | Ligand-gated Ion Channels | Stable Photoreleaser Of L-glutamate | 4-Methoxy-7-nitroindolinyl-caged L-glutamate | MNIcaged-L-glutamate

Category:

Ion Channels

Ligand-gated Ion Channels

Glutamate (Ionotropic) Receptors

Miscellaneous Glutamate

Cat.No.

Product Name

1490

MNI-caged-L-glutamate

Alternative name(s):

4-Methoxy-7-nitroindolinyl-caged L-glutamate

MNI-caged-L-glutamate C14H17N3O6 (S)-a-Amino-2,3-dihydro-4-methoxy-7-nitro-d-oxo-1H-indole-1-pentanoic acid

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MNI-caged-L-glutamate

Other Information:

Sold under licence from the Medical Research Council

Chemical Name: (S)-a-Amino-2,3-dihydro-4-methoxy-7-nitro-d-oxo-1H-indo le-1-pentanoic acid

Biological Activity:

Caged glutamate that rapidly and efficiently releases glutamate when photolysed. Water-soluble, highly resistant to hydrolysis, stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to mM concentrations). 2.5-fold more efficient at releasing L-glutamate than NI-caged L-glutamate.

Technical Data:

M.Wt:	323.3
Formula:	C₁₄H₁₇N₃O₆
Storage:	Desiccate at -20°C
Solubility:	Soluble to 50 mM in Water
Purity:	>98%
CAS No:	[295325-62-1]

Resources:

Certificate of Analysis / MSDS:

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References:

Papageorgiou and Corrie (2000) Effects of aromatic substitutions on the photocleavage of 1-acyl-7-nitroindolines. Tetrahedron 56 8197. Canepari et al (2001) Photochemical and pharmacological evaluation of 7-nitroindolinyl- and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters. J.Neurosci.Methods 112 29. Matsuzaki et al (2001) Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nature Neurosci. 4 1086. Matsuzaki et al (2004) Structural basis of long-term potentiation in single dendritic spines. Nature 429 761.

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Keywords: MNI-caged-L-glutamate, Ligand-gated Ion Channels, Stable Photoreleaser Of L-glutamate, 4-Methoxy-7-nitroindolinyl-caged L-glutamate, MNIcaged-L-glutamate, Tocris Bioscience

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