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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowAntagonists
Cat.No. Product Name
1356 MG 624
Price and Availability

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MG 624
Chemical Name: N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanamini um iodide

Biological Activity:

A selective antagonist for neuronal α7 subunit- containing nAChR subtypes. Inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively.

Technical Data:

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M.Wt: 451.39
Formula: C22H30NOI
Storage: Store at RT
Solubility: Soluble to 20 mM in DMSO and to 10 mM in Ethanol
Purity: >98%
CAS No: [77257-42-2]

Resources:

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    References:

    Gotti et al (1998) 4-Oxystilbene compounds are selective ligands for neuronal nicotinic αbungarotoxin receptors. Br.J.Pharmacol. 124 1197. Maggi et al (1999) Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick α7 nicotinic receptor. Br.J.Pharmacol. 126 285.
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    Keywords: MG 624, Ligand-gated Ion Channels, A7 Neuronal Nicotinic Receptor Antagonist, MG624, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Nicotinic ACh Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    Product Feature
    Nicotinic Receptors
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