MEN 10376 | Peptides (Neuropeptides) | Potent, Selective NK2 Antagonist | MEN10376

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Cat.No.	Product Name
1632	MEN 10376

Price and Availability

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MEN 10376

Biological Activity:

Potent and selective NK₂ receptor antagonist (pA₂ = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK₁ (pA₂ = 5.66, guinea pig ileum) and NK₃ (K_i > 10 μM, guinea pig brain). Active in vivo.

Technical Data:

M.Wt:	1081.24
Formula:	C₅₇H₆₈N₁₂O₁₀
Storage:	Desiccate at -20°C
CAS No:	[135306-85-3]

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References:

Maggi et al (1991) In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J.Pharmacol.Exp.Ther. 257 1172. Bartho et al (1992) Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK₂ receptors. Br.J.Pharmacol. 105 805. Subramanian et al (1994) Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK₂ receptor transfected cell line. Biochem.Biophys.Res.Comm. 200 1512.

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Keywords: MEN 10376, Peptides (Neuropeptides), Potent, Selective NK2 Antagonist, MEN10376, Tocris Bioscience

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Tachykinin Receptor Compounds
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