MAP4 | Glutamate (Metabotropic) Receptors | Potent Group II MGlu Agonist. Also Specific Group III MGlu Antagonist

Category:

Cat.No.	Product Name
0711	MAP4

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MAP4

Chemical Name: (S)-2-Amino-2-methyl-4-phosphonobutanoic acid

Biological Activity:

Selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.

Technical Data:

M.Wt:	197.13
Formula:	C₅H₁₂NO₅P
Storage:	Store at RT
Solubility:	Soluble to 100 mM in 1eq. NaOH and to 100 mM in Water
Purity:	>99%
CAS No:	[157381-42-5]

Resources:

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References:

Jane et al (1994) Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord. Br.J.Pharmacol. 112 809. Salt and Eaton (1995) Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65 5. Kemp et al (1996) Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur.J.Pharmacol. 309 79. Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493.

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Keywords: MAP4, Glutamate (Metabotropic) Receptors, Potent Group II MGlu Agonist. Also Specific Group III MGlu Antagonist, Tocris Bioscience

Literature in this Area

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Metabotropic Glutamate Receptors
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The Ins & outs of Glutamate Transporter Pharmacology
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