Tocris Bioscience
 Welcome to Tocris

Home Products Technical Support Customer Support Literature Custom Synthesis
Category: 7TM ReceptorsarrowCannabinoid ReceptorsarrowOther Cannabinoids
Cat.No. Product Name
1421 MAFP
Price and Availability

Click here for full price details of
MAFP
Chemical Name: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methyl ester phosphonofluoridic acid

Biological Activity:

Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC50 = 2.5 nM). Also binds irreversibly to CB1 receptors (IC50 = 20 nM).

Technical Data:

 Click here for more information on batch specific data
M.Wt: 370.49
Formula: C21H36FO2P
Storage: Desiccate at -20°C
Solubility: Soluble in Ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
CAS No: [188404-10-6]

Resources:

    		•

    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    For specific/earlier batch please select:  
    Product/Material Safety Data Sheet: View current batch
    For specific/earlier batch please select:  

    References:

    De Petrocellis et al (1997) Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem.Biophys.Res.Comm. 231 82. Deutsch et al (1997) Methyl arachidonyl fluorophosphate: a potent irreversible inhibitor of anandamide amidase. Biochem.Pharmacol. 53 255. Martin et al (2000) Cannabinoid properties of methylfluorophosphonate analogs. J.Pharmacol.Exp.Ther. 294 1209.
    View related products by Pharmacological Action or by Research Area

    Keywords: MAFP, Cannabinoid Receptors, Potent, Irreversible Anandamide Amidase Inhibitor, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Cannabinoid Receptors
    Request Copy | Download PDF
    Featured New Product
    Highly selective CB2 agonist
    2764   Gp 1a
    Highly selective CB2 receptor agonist; Ki values are 0.037 and 363 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
    View all Featured New Products
    New Products in this Area

     2797O-1602
     Potent GPR55 receptor agonist
     2680O-2545 hydrochloride
     High affinity, water-soluble CB1/CB2 agonist
     2836Arachidonyl serotonin
     Dual FAAH/TRPV1 blocker
     2764GP 1a
     Highly selective CB2 agonist
     2678GP 2a
     Selective CB2 agonist
     2663CB 65
     High affinity, selective CB2 agonist
     2288O-1918
     Silent antagonist for putative abnormal-CBD receptor
     2434L-759,656
     Highly selective CB2 agonist
     2231Anti-CB2
     Antibody recognising CB2 receptors
    Sign-up for new product e-alerts
    Log In / Register

    User ID
    Password
    If you are not registered with us Create Account
    Home | About | Contact | Environment | Distributors | Glossary | Ordering | Security | Privacy | Terms & Conditions | Services | Site Map