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Category:
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Other Activities Miscellaneous Compounds
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Cat.No.
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Product Name
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2874 |
Luteolin
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| Alternative name(s): |
3',4',5,7-Tetrahydroxyflavone |
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Price and Availability
Click here for full price details of
Luteolin
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Chemical Name:
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4
-one |
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Biological Activity:
Anti-inflammatory, antioxidant and free radical
scavenger. Inhibits LPS-induced TNF-α, IL-6 and
inducible nitric oxide production and blocks NF-κB and AP-1
activation. Antiproliferative; inhibits proliferation of Lewis lung carcinoma
cells in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Kim et al (2007) Caspase
activation and extracellular signal-regulated kinase/Akt inhibition were
involved in luteolin-induced apoptosis in Lewis lung carcinoma cells.
Ann.N.Y.Acad.Sci. 1090 597. Ju et al (2007) A
critical role of luteolin-induced reactive oxygen species in blockage of tumour
necrosis factor-activated nuclear factor-κB pathway and sensitization of
apoptosis in lung cancer cells. Mol.Pharmacol. 71 1381. Chen
et al (2007) Luteolin suppresses inflammation-associated gene expression
by blocking NF-κB and AP-1
activation pathway in mouse alveolar macrophage. Life Sci. (in press).
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or by Research Area
Keywords: Luteolin, Anti-inflammatory, Antioxidant & Free Radical Scavenger, 3,4,5,7-Tetrahydroxyflavone, Tocris Bioscience
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