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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowOther
Cat.No. Product Name
1295 Loreclezole hydrochloride
Price and Availability

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Loreclezole hydrochloride
Chemical Name: (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4 -triazole hydrochloride

Biological Activity:

Subtype selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitisation. Inhibits homomeric r1 GABAC receptors.

Technical Data:

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M.Wt: 311
Formula: C10H6Cl3N3.HCl
Storage: Desiccate at -20°C
Solubility: Soluble to 5 mM in DMSO and to 5 mM in Ethanol
Purity: >99%
CAS No: [117857-45-1]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Donnelly and Macdonald (1996) Loreclezole enhances apparent desensitisation of recombinant GABAA receptor currents. Neuropharmacology 35 1233. Fisher et al (2000) Loreclezole inhibition of recombinant α1β1γ2L GABAA receptor single channel currents. Neuropharmacology 39 235. Thomet et al (2000) Loreclezole as a simple functional marker for homomeric r  type GABAC receptors. Eur.J.Pharmacol. 408 R1. Smith et al (2004) Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 311 601.
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    Keywords: Loreclezole Hydrochloride, Ligand-gated Ion Channels, Subtype-selective GABAA Receptor Modulator, Tocris Bioscience
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