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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowAgonists
Cat.No. Product Name
1077 (-)-Lobeline hydrochloride
Price and Availability

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Lobeline hydrochloride
Chemical Name: 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-pipe ridinyl]acetophenone hydrochloride

Biological Activity:

High affinity nicotinic receptor ligand, with a Ki value of 4.4 nM in rat brain.

Technical Data:

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M.Wt: 373.92
Formula: C22H27NO2.HCl
Storage: Store at RT
Solubility: Soluble to 50 mM in Ethanol and to 10 mM in Water
CAS No: [134-63-4]

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    References:

    Merck Index 12 5580. Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410. LiHong et al (1998) Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine. J.Neurochem. 71 258. Sántha et al (2000) Multiple cellular mechanisms mediate the effect of lobeline or the release of norepinephrine. J.Pharmacol.Exp.Ther. 294 302.
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    Keywords: Lobeline Hydrochloride, Ligand-gated Ion Channels, Nicotinic Agonist, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Nicotinic ACh Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    Product Feature
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