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Category:
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Cellular Processes and Components Other Signal TransductionProtein translocation/Exocytosis/Endocytosis
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Cat.No.
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Product Name
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2839 |
Levetiracetam
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| Alternative name(s): |
Keppra |
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UCB L059 |
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Price and Availability
Click here for full price details of
Levetiracetam
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Chemical Name:
(2S)-(2-Oxopyrrolidin-1-yl)butyramide |
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Biological Activity:
Antiepileptic that displays
distinctive properties from conventional antiepileptic drugs. Displays potent
seizure protection in animal models of chronic epilepsy but lacks activity in
acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+
dependent Cl-/HCO3- exchange.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Lynch et al
(2004) The synaptic vesicle protein SV2A is the binding site for the
antiepileptic drug levetiracetam. Proct.Natl.Acad.Sci. USA 101
9861. Smedt et al (2007) Levetiracetam: the profile of a novel
anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 13
43. Ueda et al (2007) Effect of levetiracetam on molecular
regulation of hippocampal glutamate and GABA transporters in rats with chronic
seizures induced by amygdalar FeCl3 injection. Brain Res. 1151
55.
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View related products by Pharmacological Action
or by Research Area
Keywords: Levetiracetam, Other Signal Transduction, Anti-epileptic; Binds SV2A, Keppra, UCB L059, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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