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Category:
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Enzymes Oxygenases/OxidasesMonoamine Oxidase
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Cat.No.
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Product Name
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2460 |
Lazabemide hydrochloride
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| Alternative name(s): |
Ro 19-6327 |
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Price and Availability
Click here for full price details of
Lazabemide
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Chemical Name:
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide
hydrochloride |
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Biological Activity:
Selective, reversible monoamine
oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM
for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high
concentrations (IC50 values are 86, 123 and > 500 μM
for noradrenalin, serotonin and dopamine uptake respectively).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Saura et al
(1992) Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro
19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat
CNS, peripheral organs, and human brain. J.Neurosci. 12 1977. Bondiolotti
et al (1995) In vitro effects on monoamine uptake and
release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide:
a comparison with L-deprenyl. Biochem.Pharmacol. 50
97. Guimaraes and Soares-da-Silva (1998) The activity of MAO A and B in
rat renal cells and tubules. Life Sci. 62 727.
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or by Research Area
Keywords: Lazabemide, Oxygenases / Oxidases, Selective MAO-B Inhibitor, Ro 19-6327, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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