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Lavendustin A
Chemical Name:5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methy
l]amino]-2-hydroxybenzoic acid
Biological Activity:
Potent, cell-permeable inhibitor of epidermal growth factor
receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src
with an IC50 of 500 nM and is selective over PKA, PKC and PI
3-kinase (IC50 > 100 μM).
Onoda et al (1989) Isolation of a novel tyrosine kinase inhibitor, lavendustin
A, from streptomyces griseolavendus.J.Nat.Prod. 52
1252. O'Dellet al (1991) Long-term potentiation in the
hippocampus is blocked by tyrosine kinase inhibitors. Nature 353
558. Hsuet al (1991) Kinetic analysis of the inhibition of the
epidermal growth factor receptor tyrosine kinase by lavendustin-A and its
analogue. J.Biol.Chem. 266 21105.
