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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowMiscellaneous Glutamate
Cat.No. Product Name
1611 Lamotrigine
Price and Availability

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Lamotrigine

Other Information:

Sold for research purposes under agreement from GlaxoSmithKline
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine

Biological Activity:

Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.

Technical Data:

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M.Wt: 256.09
Formula: C9H7Cl2N5
Storage: Store at RT
Solubility: Soluble to 10 mM in Ethanol and to 100 mM in DMSO
Purity: >99%
CAS No: [84057-84-1]

Resources:

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    References:

    Leach et al (1991) Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 S4. Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522. Grunze et al (1998) Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 38 131.
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    Keywords: Lamotrigine, Ligand-gated Ion Channels, Inhibits Glutamate Release. Anticonvulsant, Tocris Bioscience
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