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Category: EnzymesarrowKinasesarrowBTK
Cat.No. Product Name
1300 LFM-A13
Price and Availability

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LFM-A13
Chemical Name: 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

Biological Activity:

Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM.

Technical Data:

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M.Wt: 360
Formula: C11H8Br2N2O2
Storage: Store at RT
Solubility: Soluble to 50 mM in Ethanol and to 5 mM in 1eq. NaOH
Purity: >99%
CAS No: [62004-35-7]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Mahajan et al (1999) Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]. J.Biol.Chem. 274 9587. Vassilev et al (1999) Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. J.Biol.Chem. 274 1646. Crosby and Poole (2002) Interaction of Bruton's tyrosine kinase and protein kinase Cq in platelets. J.Biol.Chem. 277 9958.
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    Keywords: LFM-A13, Kinases, Potent, Selective BTK Inhibitor, LFMA13, Tocris Bioscience
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