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Category:
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7TM Receptors Dopamine ReceptorsD1-like Receptors
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Cat.No.
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Product Name
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1674 |
LE 300
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Price and Availability
Click here for full price details of
LE 300
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Chemical Name:
6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f][3]ben
zazecine |
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Biological Activity:
Potent
and selective dopamine D1 receptor antagonist (Ki values
are 0.08-1.9 nM and 6-45 nM for D1 and D2 receptors
respectively). Also displays moderate affinity for the 5-HT2A
receptor (Ki = 20 nM). Active in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Witt et al (2000)
7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine:
a new heterocyclic system and a new lead compound for dopamine receptor
antagonists. J.Med.Chem. 43 2079. Kassack et al
(2002) Pharmacological characterization of the benz[d]indolo[2,3-g]azecine
LE300, a novel type of a nanomolar dopamine receptor antagonist.
Naunyn-Schmied.Arch.Pharmacol. 366 543. El-Subbagh et
al (2002) Dopamine/serotonin receptor ligands: Part IV [1]: Synthesis and
pharmacology of novel 3-benzazecines and 3-benzazonines as potential 5-HT2A
and dopamine receptor ligands. Arch.Pharm.Pharm.Med.Chem. 9 443.
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or by Research Area
Keywords: LE 300, Dopamine Receptors, Potent & Selective Dopamine D1 Antagonist, LE300, Tocris Bioscience
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