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Category:
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7TM Receptors Cannabinoid ReceptorsCB2 Receptors
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Cat.No.
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Product Name
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2434 |
L-759,656
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Price and Availability
Click here for full price details of
L-759656
Other Information:
Local regulations may restrict the sale of this
product in some countries: Canadian customers require a CDSA import permit
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Chemical Name:
(6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,8,9,10,10a-hexah
ydro-1-methoxy-6,6-dimethyl-9-methylene-6H-dibenzo[b,d]
pyran |
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Biological Activity:
Highly selective CB2
receptor agonist (Ki values are 11.8 and 4888 nM for CB2
and CB1 receptors respectively). Potently inhibits
forskolin-stimulated cAMP production via CB2 receptors expressed in
CHO cells (EC50 = 3.1 nM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ross
et al (1999) Agonist-inverse agonist
characterization at CB1 and CB2 cannabinoid receptors of
L759633, L759656 and AM630. Br.J.Pharmacol. 126 665. Huffman
(2000) The search for selective ligands for the CB2 receptor.
Curr.Pharmaceut.Des. 6 1323. Huffman (2005) CB2
receptor ligands. Mini Rev.Med.Chem. 5 641.
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or by Research Area
Keywords: L-759656, Cannabinoid Receptors, Highly Selective CB2 Agonist, L759656, Tocris Bioscience
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