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Category:
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7TM Receptors Dopamine ReceptorsD2-like ReceptorsD4-selective
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Cat.No.
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Product Name
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1004 |
L-741,742 hydrochloride
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Price and Availability
Click here for full price details of
L-741,742 hydrochloride
Other Information:
Sold with the permission of Merck Sharp and Dohme
Ltd
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Chemical Name:
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperid
in-4-yl)isoxazole hydrochloride |
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Biological Activity:
A potent and highly selective D4 dopamine receptor
antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned
human D2, D3 and D4 receptors.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Rowley et al (1996)
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a
potent, selective antagonist at human cloned dopamine D4 receptors.
J. Med. Chem. 39 1943. Rowley et al (1997)
4-Heterocyclylpiperidines as selective high-affinity ligands at the human
dopamine D4 receptor. J.Med.Chem. 40 2374.
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or by Research Area
Keywords: L-741,742 Hydrochloride, Dopamine Receptors, Highly Selective D4 Antagonist, L741,742 Hydrochloride, Tocris Bioscience
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