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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowGlycine SitearrowAntagonists
Cat.No. Product Name
0705 L-701,252  
Price and Availability

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L-701,252

Other Information:

Sold with the permission of Merck Sharp and Dohme Ltd
Chemical Name: 7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinol inone

Biological Activity:

An antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant.

Technical Data:

 Click here for more information on batch specific data
M.Wt: 263.68
Formula: C13H10ClNO3
Storage: Desiccate at +4°C
Solubility: Soluble to 50 mM in DMSO
Purity: >99%
CAS No: [151057-13-5]

Resources:

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    • Certificate of Analysis / MSDS:

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    References:

    Rowley et al (1993) 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex. J.Med.Chem. 36 3386. Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149.

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    Keywords: L-701,252, Ligand-gated Ion Channels, NMDA Antagonist, Acts Glycine Site, L701,252, Tocris Bioscience
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