L-694,247 | 5-HT Receptors | 5-HT1D Agonist | L694,247

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Cat.No.	Product Name
0781	L-694,247

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L-694,247

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Sold with the permission of Merck Sharp and Dohme Ltd

Chemical Name: 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5 -yl]-1H-indol-3-yl]ethanamine

Biological Activity:

Selective and extremely potent 5-HT_1Dreceptor agonist.

Technical Data:

M.Wt:	411.48
Formula:	C₂₀H₂₁N₅O₃S
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[137403-12-4]

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References:

Street et al (1993) Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT_1D receptors. J.Med.Chem. 36 1529. Beer et al (1993) L-694,247: a potent 5-HT_1D receptor antagonist. Br.J.Pharmacol. 110 1196. Heald et al (1994) [³H]L-694,247 labels the 5-HT_1D_β receptor in pig caudate membranes. Eur.J.Pharmacol. 264 213. Buhlen et al (1996) Evidence for presynaptic location of inhibitory 5-HT_1D_β -like autoreceptors in the guinea-pig brain cortex. Naunym-Schmied.Arch.Pharmacol. 353 281.

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Keywords: L-694,247, 5-HT Receptors, 5-HT1D Agonist, L694,247, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
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