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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowGlycine SitearrowAntagonists
Cat.No. Product Name
0742 L-689,560  
Price and Availability

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L-689,560

Other Information:

Sold with the permission of Merck Sharp and Dohme Ltd
Chemical Name: trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino -1,2,3,4-tetrahydroquinoline

Biological Activity:

Very potent antagonist at the glycine-NMDA site.

Technical Data:

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M.Wt: 380.23
Formula: C17H15Cl2N3O3
Storage: Store at RT
Solubility: Soluble to 25 mM in DMSO and to 100 mM in Ethanol
CAS No: [139051-78-8]

Resources:

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    • Certificate of Analysis / MSDS:

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    References:

    Leeson et al (1991) trans-2-Carboxy-4-substituted tetrahydroquinolines. Potent glycine-site NMDA receptor antagonists. Med.Chem.Res. 1 64. Leeson et al (1992) 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationship for antagonism at the glycine site of the NMDA receptor. J.Med.Chem. 35 1954. Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149.

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    Keywords: L-689,560, Ligand-gated Ion Channels, Very Potent NMDA Antagonist, L689,560, Tocris Bioscience
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