L-655,708 | Ligand-gated Ion Channels | Selective For A5-containing GABAA Receptors | L655,708

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Cat.No.	Product Name
1327	L-655,708

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L-655,708

Chemical Name: 11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5- a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester

Biological Activity:

Potent, selective inverse agonist for the benzodiazepine site of GABA_A receptors containing the α5 subunit (K_i = 0.45 nM). Displays 50-100-fold selectivity over GABA_A receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Technical Data:

M.Wt:	341.37
Formula:	C₁₈H₁₉N₃O₄
Storage:	Desiccate at +4°C
Solubility:	Soluble to 5 mM in DMSO and to 10 mM in 1eq. HCl
Purity:	>99%
CAS No:	[130477-52-0]

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References:

Quirk et al (1996) [³H]L-655,708, a novel ligand selective for the benzodiazepine site of GABA_A receptors which contain the α5 subunit. Neuropharmacology 35 1331. Sur et al (1998) Rat and human hippocampal α5 subunit-containing γ-aminobutyric acid_A receptors have α5β3γ2 pharmacological characteristics. Mol.Pharmacol. 54 928. Atack et al (2006) L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABA_A receptors. Neuropharmacology 51 1023.

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Keywords: L-655,708, Ligand-gated Ion Channels, Selective For A5-containing GABAA Receptors, L655,708, Tocris Bioscience

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